Assay Detail
Binding
CHEMBL3880776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT2A receptor (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH/3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.99 | 10.65 |
| pEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 10.65 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 8.75 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.05 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.73 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 6.85 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 5.93 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | - |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | EC50 | = | 0.02239 | nM | 10.65 |
| CHEMBL493 | BROMOCRIPTINE | EC50 | = | 1.778 | nM | 8.75 |
| CHEMBL531 | PERGOLIDE | EC50 | = | 8.913 | nM | 8.05 |
| CHEMBL39 | SEROTONIN | EC50 | = | 18.62 | nM | 7.73 |
| CHEMBL589 | ROPINIROLE | EC50 | = | 141.25 | nM | 6.85 |
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL53 | APOMORPHINE | pEC50 | - | — | - | |
| CHEMBL59 | DOPAMINE | pEC50 | - | — | - |