Assay Detail
Binding
CHEMBL3880853
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Inhibition of MEK1 (unknown origin) using ERK2 as substrate after 40 mins by ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multikinase inhibitors for use in the treatment of cancer
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.83 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097700 | — | — | 1 | 8.55 |
| CHEMBL3957257 | — | — | 1 | 8.32 |
| CHEMBL3900978 | — | — | 1 | 8.02 |
| CHEMBL1097999 | E-6201 | 2.0 | 1 | 7.89 |
| CHEMBL3970061 | — | — | 1 | 7.25 |
| CHEMBL3893740 | — | — | 1 | 7.10 |
| CHEMBL3974111 | — | — | 1 | 7.04 |
| CHEMBL1097699 | — | — | 1 | 7.04 |
| CHEMBL3915384 | — | — | 1 | 7.00 |
| CHEMBL3986872 | — | — | 1 | 6.92 |
| CHEMBL3948014 | — | — | 1 | 6.84 |
| CHEMBL3931700 | — | — | 1 | 6.76 |
| CHEMBL3940603 | — | — | 1 | 6.74 |
| CHEMBL3922219 | — | — | 1 | 6.73 |
| CHEMBL3898203 | — | — | 1 | 6.73 |
| CHEMBL3898540 | — | — | 1 | 6.62 |
| CHEMBL3914342 | — | — | 1 | 6.50 |
| CHEMBL3973244 | — | — | 1 | 6.45 |
| CHEMBL3956374 | — | — | 1 | 6.45 |
| CHEMBL3950457 | — | — | 1 | 6.44 |
| CHEMBL3895505 | — | — | 1 | 6.38 |
| CHEMBL3933684 | — | — | 1 | 6.33 |
| CHEMBL3967300 | — | — | 1 | 6.32 |
| CHEMBL3912705 | — | — | 1 | 6.18 |
| CHEMBL3970354 | — | — | 1 | 6.18 |
| CHEMBL3936269 | — | — | 1 | 6.18 |
| CHEMBL3963562 | — | — | 1 | 6.12 |
| CHEMBL3954863 | — | — | 1 | 6.07 |
| CHEMBL3925395 | — | — | 1 | - |
| CHEMBL3943250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097700 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3957257 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3900978 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL1097999 | E-6201 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3970061 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3893740 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3974111 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1097699 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3915384 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3986872 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3948014 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL3931700 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL3940603 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3922219 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3898203 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3898540 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3914342 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL3973244 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL3956374 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL3950457 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL3895505 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL3933684 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL3967300 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL3912705 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL3970354 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL3936269 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL3963562 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL3954863 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL3925395 | — | IC50 | > | 330.0 | nM | - |
| CHEMBL3943250 | — | IC50 | > | 330.0 | nM | - |