Assay Detail

CHEMBL3880893

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human COLO205 cells expressing B-RAF V600E mutant assessed as reduction in cell viability after 96 hrs by CellTiter-Glo luminescence assay or methylene blue assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	COLO 205
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Multikinase inhibitors for use in the treatment of cancer

(2009)

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.47	7.57

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1097700	—	—	1	7.57
CHEMBL1097999	E-6201	2.0	1	7.37

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1097700	—	IC50	=	27.0	nM	7.57
CHEMBL1097999	E-6201	IC50	=	43.0	nM	7.37