Assay Detail
Functional
CHEMBL3881041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as reduction in cell viability preincubated for 1 hr followed by addition of VEGF measured after 72 hrs in presence of albumin by MTT assay
133
Total Activities
133
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 133 | 7.96 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3911428 | — | — | 1 | 9.00 |
| CHEMBL3914097 | — | — | 1 | 9.00 |
| CHEMBL3910043 | — | — | 1 | 9.00 |
| CHEMBL3965452 | — | — | 1 | 8.82 |
| CHEMBL3965277 | — | — | 1 | 8.80 |
| CHEMBL3906315 | — | — | 1 | 8.70 |
| CHEMBL3962576 | — | — | 1 | 8.68 |
| CHEMBL3955019 | — | — | 1 | 8.66 |
| CHEMBL3960830 | — | — | 1 | 8.64 |
| CHEMBL3891895 | — | — | 1 | 8.59 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 8.57 |
| CHEMBL3899112 | — | — | 1 | 8.57 |
| CHEMBL3930485 | — | — | 1 | 8.57 |
| CHEMBL3905305 | — | — | 1 | 8.55 |
| CHEMBL3963146 | — | — | 1 | 8.54 |
| CHEMBL3985150 | — | — | 1 | 8.52 |
| CHEMBL3899609 | — | — | 1 | 8.48 |
| CHEMBL3936736 | — | — | 1 | 8.44 |
| CHEMBL3925024 | — | — | 1 | 8.42 |
| CHEMBL3904168 | — | — | 1 | 8.42 |
| CHEMBL3914819 | — | — | 1 | 8.41 |
| CHEMBL3900618 | — | — | 1 | 8.40 |
| CHEMBL3545335 | AG-13958 | 2.0 | 1 | 8.40 |
| CHEMBL3984641 | — | — | 1 | 8.39 |
| CHEMBL3915607 | — | — | 1 | 8.36 |
| CHEMBL3959357 | — | — | 1 | 8.35 |
| CHEMBL3904608 | — | — | 1 | 8.34 |
| CHEMBL3911423 | — | — | 1 | 8.34 |
| CHEMBL3920383 | — | — | 1 | 8.33 |
| CHEMBL3963477 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3911428 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3910043 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3914097 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3965452 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3965277 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3906315 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3962576 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3955019 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3960830 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3891895 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3930485 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3899112 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3905305 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3963146 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3985150 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3899609 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3936736 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3904168 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3925024 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3914819 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3545335 | AG-13958 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3900618 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3984641 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3915607 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3959357 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3911423 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3904608 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3920383 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3963477 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3899028 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3907423 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3959310 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3891979 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3947527 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3949546 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3899200 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3951147 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3967940 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3925855 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3986951 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3894732 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3963347 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3933175 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3900801 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3958163 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3947493 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3912174 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3896427 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3952496 | — | IC50 | = | 8.0 | nM | 8.10 |