Compound Detail
CHEMBL3967940
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Basic Information
| ChEMBL ID | CHEMBL3967940 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SZIKBPJKTWBVEC-SDNWHVSQSA-N |
2
Targets
2
Activities
2
Assay Types
5
PK Parameters
0
Publications
0
Known Names
Molecular Properties
480.6
MW (Da)
6.35
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.28
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.24
Ki 1 meas. best 9.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 9.96 | 9.96 | 0.1 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 8.24 | 8.24 | 5.8 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 6301.0 | ng.hr.mL-1 | Mus musculus |
| AUClast | - | - | Mus musculus |
| Cmax | 8323.45 | nM | Mus musculus |
| Cmax | - | - | Mus musculus |
| T1/2 | 1.7 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | Ki | = | 0.11 | nM | 9.96 | Inhibition of unphosphorylated human 50 residues truncated cytoplasmic domain of... | - |
| NON-PROTEIN TARGET | IC50 | = | 5.8 | nM | 8.24 | Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as reduc... | - |
Data from ChEMBL 36 via Core Engine