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Assay Detail

CHEMBL3882759

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human full length EGFR expressed in baculovirus expression system assessed as decrease in transfer of gamma-phosphate from ATP onto tyrosine residue of biotinylated peptide substrate preincubated for 1 hr followed by substrate addition measured after 90 mins by HTRF method
ChEMBL ↗
250
Total Activities
250
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Epidermal growth factor receptor (CHEMBL203) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Imidazopyridine Kinase Inhibitors
(2008)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 250 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3897153 — — 1 6.00
CHEMBL3904450 — — 1 6.00
CHEMBL3969511 — — 1 6.00
CHEMBL3934556 — — 1 6.00
CHEMBL3943489 — — 1 6.00
CHEMBL3915202 — — 1 6.00
CHEMBL3976571 — — 1 6.00
CHEMBL3937417 — — 1 6.00
CHEMBL3937303 — — 1 6.00
CHEMBL3955829 — — 1 6.00
CHEMBL3950296 — — 1 6.00
CHEMBL3907756 — — 1 6.00
CHEMBL3905921 — — 1 6.00
CHEMBL3954571 — — 1 6.00
CHEMBL3923275 — — 1 6.00
CHEMBL3985011 — — 1 6.00
CHEMBL3940401 — — 1 6.00
CHEMBL3906473 — — 1 6.00
CHEMBL3957976 — — 1 -
CHEMBL3942220 — — 1 -
CHEMBL3932468 — — 1 -
CHEMBL3980871 — — 1 -
CHEMBL3978486 — — 1 -
CHEMBL3982471 — — 1 -
CHEMBL3919333 — — 1 -
CHEMBL3930609 — — 1 -
CHEMBL3926128 — — 1 -
CHEMBL3928784 — — 1 -
CHEMBL3911340 — — 1 -
CHEMBL3918937 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3906473 — IC50 = 1000.0 nM 6.00
CHEMBL3955829 — IC50 = 1000.0 nM 6.00
CHEMBL3905921 — IC50 = 1000.0 nM 6.00
CHEMBL3907756 — IC50 = 1000.0 nM 6.00
CHEMBL3943489 — IC50 = 1000.0 nM 6.00
CHEMBL3937303 — IC50 = 1000.0 nM 6.00
CHEMBL3934556 — IC50 = 1000.0 nM 6.00
CHEMBL3954571 — IC50 = 1000.0 nM 6.00
CHEMBL3937417 — IC50 = 1000.0 nM 6.00
CHEMBL3969511 — IC50 = 1000.0 nM 6.00
CHEMBL3904450 — IC50 = 1000.0 nM 6.00
CHEMBL3923275 — IC50 = 1000.0 nM 6.00
CHEMBL3915202 — IC50 = 1000.0 nM 6.00
CHEMBL3950296 — IC50 = 1000.0 nM 6.00
CHEMBL3985011 — IC50 = 1000.0 nM 6.00
CHEMBL3897153 — IC50 = 1000.0 nM 6.00
CHEMBL3940401 — IC50 = 1000.0 nM 6.00
CHEMBL3976571 — IC50 = 1000.0 nM 6.00
CHEMBL3960482 — IC50 < 100.0 nM -
CHEMBL3957811 — IC50 < 100.0 nM -
CHEMBL3923001 — IC50 < 1000.0 nM -
CHEMBL3913225 — IC50 < 1000.0 nM -
CHEMBL3986506 — IC50 < 100.0 nM -
CHEMBL3891415 — IC50 < 100.0 nM -
CHEMBL3972006 — IC50 < 1000.0 nM -
CHEMBL3973106 — IC50 < 100.0 nM -
CHEMBL3963200 — IC50 < 100.0 nM -
CHEMBL3894261 — IC50 < 100.0 nM -
CHEMBL3950784 — IC50 < 1000.0 nM -
CHEMBL3953464 — IC50 < 1000.0 nM -
CHEMBL3890844 — IC50 < 1000.0 nM -
CHEMBL3915736 — IC50 < 100.0 nM -
CHEMBL3940382 — IC50 < 1000.0 nM -
CHEMBL3919366 — IC50 < 1000.0 nM -
CHEMBL3983732 — IC50 < 100.0 nM -
CHEMBL3974124 — IC50 < 100.0 nM -
CHEMBL3964932 — IC50 < 100.0 nM -
CHEMBL3969290 — IC50 < 1000.0 nM -
CHEMBL3957456 — IC50 < 1000.0 nM -
CHEMBL3908198 — IC50 < 1000.0 nM -
CHEMBL3905410 — IC50 < 100.0 nM -
CHEMBL3953680 — IC50 < 1000.0 nM -
CHEMBL3951002 — IC50 < 1000.0 nM -
CHEMBL3893256 — IC50 < 100.0 nM -
CHEMBL3919927 — IC50 < 1000.0 nM -
CHEMBL3976565 — IC50 < 1000.0 nM -
CHEMBL3967372 — IC50 < 1000.0 nM -
CHEMBL3910511 — IC50 < 1000.0 nM -
CHEMBL3913169 — IC50 < 100.0 nM -
CHEMBL3896493 — IC50 < 1000.0 nM -