Compound Detail
CHEMBL3980871
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CN(C)CCOc1cccc(Nc2nccc(-c3c(-c4cccc(C(=O)Nc5c(F)cc(F)cc5F)c4)nc4ccccn34)n2)c1
Basic Information
| ChEMBL ID | CHEMBL3980871 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WTWCKEAQEJKCEA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
623.6
MW (Da)
6.81
ALogP
8
HBA
2
HBD
96.7
PSA (Ų)
0.17
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 100.0 | nM | 7.0 | Inhibition of IGF1-induced human IGF1R autophosphorylation expressed in mouse NI... | - |
Data from ChEMBL 36 via Core Engine