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Assay Detail

CHEMBL3883019

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IGF1-induced human IGF1R autophosphorylation expressed in mouse NIH-3T3 cells preincubated for 2 hrs followed by IGF-1 induction measured after 15 mins by DELFIA
ChEMBL ↗
247
Total Activities
247
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type NIH3T3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Insulin-like growth factor 1 receptor (CHEMBL1957) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Imidazopyridine Kinase Inhibitors
(2008)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 247 7.00 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3957642 — — 1 7.00
CHEMBL3957811 — — 1 7.00
CHEMBL3907857 — — 1 7.00
CHEMBL3894261 — — 1 7.00
CHEMBL3915736 — — 1 7.00
CHEMBL3936478 — — 1 7.00
CHEMBL3938043 — — 1 7.00
CHEMBL3898403 — — 1 7.00
CHEMBL3968197 — — 1 7.00
CHEMBL3918852 — — 1 7.00
CHEMBL3922419 — — 1 7.00
CHEMBL3908294 — — 1 7.00
CHEMBL3915209 — — 1 7.00
CHEMBL3984698 — — 1 7.00
CHEMBL3889680 — — 1 7.00
CHEMBL3928784 — — 1 7.00
CHEMBL3917543 — — 1 7.00
CHEMBL3981747 — — 1 7.00
CHEMBL3954571 — — 1 7.00
CHEMBL3957183 — — 1 7.00
CHEMBL3909929 — — 1 7.00
CHEMBL3901819 — — 1 7.00
CHEMBL448668 — — 1 7.00
CHEMBL3956956 — — 1 7.00
CHEMBL3957976 — — 1 7.00
CHEMBL3980871 — — 1 7.00
CHEMBL3978486 — — 1 7.00
CHEMBL3985011 — — 1 7.00
CHEMBL3982471 — — 1 7.00
CHEMBL3930609 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3982471 — IC50 = 100.0 nM 7.00
CHEMBL3957183 — IC50 = 100.0 nM 7.00
CHEMBL3909929 — IC50 = 100.0 nM 7.00
CHEMBL3898403 — IC50 = 100.0 nM 7.00
CHEMBL3901819 — IC50 = 100.0 nM 7.00
CHEMBL3936478 — IC50 = 100.0 nM 7.00
CHEMBL3928784 — IC50 = 100.0 nM 7.00
CHEMBL3930609 — IC50 = 100.0 nM 7.00
CHEMBL3894261 — IC50 = 100.0 nM 7.00
CHEMBL3896003 — IC50 = 100.0 nM 7.00
CHEMBL3985011 — IC50 = 100.0 nM 7.00
CHEMBL3978486 — IC50 = 100.0 nM 7.00
CHEMBL3980871 — IC50 = 100.0 nM 7.00
CHEMBL3957976 — IC50 = 100.0 nM 7.00
CHEMBL3938043 — IC50 = 100.0 nM 7.00
CHEMBL448668 — IC50 = 100.0 nM 7.00
CHEMBL3956956 — IC50 = 100.0 nM 7.00
CHEMBL3907857 — IC50 = 100.0 nM 7.00
CHEMBL3954571 — IC50 = 100.0 nM 7.00
CHEMBL3915736 — IC50 = 100.0 nM 7.00
CHEMBL3922419 — IC50 = 100.0 nM 7.00
CHEMBL3940222 — IC50 = 100.0 nM 7.00
CHEMBL3918624 — IC50 = 100.0 nM 7.00
CHEMBL3908294 — IC50 = 100.0 nM 7.00
CHEMBL3915209 — IC50 = 100.0 nM 7.00
CHEMBL3984698 — IC50 = 100.0 nM 7.00
CHEMBL3889680 — IC50 = 100.0 nM 7.00
CHEMBL3957811 — IC50 = 100.0 nM 7.00
CHEMBL3957642 — IC50 = 100.0 nM 7.00
CHEMBL3917543 — IC50 = 100.0 nM 7.00
CHEMBL3918852 — IC50 = 100.0 nM 7.00
CHEMBL3968197 — IC50 = 100.0 nM 7.00
CHEMBL3981747 — IC50 = 100.0 nM 7.00
CHEMBL3941932 — IC50 < 100.0 nM -
CHEMBL3944498 — IC50 < 100.0 nM -
CHEMBL3967372 — IC50 < 100.0 nM -
CHEMBL3913169 — IC50 < 100.0 nM -
CHEMBL3910511 — IC50 < 100.0 nM -
CHEMBL3890844 — IC50 < 100.0 nM -
CHEMBL3905410 — IC50 < 100.0 nM -
CHEMBL3896138 — IC50 < 100.0 nM -
CHEMBL3908198 — IC50 < 100.0 nM -
CHEMBL3957456 — IC50 < 100.0 nM -
CHEMBL3969290 — IC50 < 100.0 nM -
CHEMBL3950784 — IC50 < 100.0 nM -
CHEMBL3915202 — IC50 < 100.0 nM -
CHEMBL3964932 — IC50 < 100.0 nM -
CHEMBL3976571 — IC50 < 100.0 nM -
CHEMBL3974124 — IC50 < 100.0 nM -
CHEMBL3953680 — IC50 < 100.0 nM -