Assay Detail
Binding
CHEMBL3992736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of GLUT4 in mouse 3T3L1 cells assessed as reduction in insulin-stimulated [3H]-2-deoxy-D-glucose uptake preincubated for 20 mins followed by measured for [3H]-2-deoxy-D-glucose addition measured after 1 to 10 mins by Lineweaver-Burk plot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 2, facilitated glucose transporter member 4 (CHEMBL1250410) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Anticancer agents interacting with membrane glucose transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.22 | 4.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431701 | SILYBIN A | 3.0 | 1 | 4.22 |
| CHEMBL315670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431701 | SILYBIN A | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL315670 | — | Ki | = | 114000.0 | nM | - |