Assay Detail
Binding
CHEMBL3993986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New quinolinic derivatives as melatonergic ligands: Synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.04 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 10.00 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.92 |
| CHEMBL4102177 | — | — | 1 | 9.52 |
| CHEMBL4084612 | — | — | 1 | 9.22 |
| CHEMBL4062947 | — | — | 1 | 9.10 |
| CHEMBL4095210 | — | — | 1 | 8.70 |
| CHEMBL4071572 | — | — | 1 | 8.70 |
| CHEMBL4079699 | — | — | 1 | 8.40 |
| CHEMBL4089965 | — | — | 1 | 8.30 |
| CHEMBL4082097 | — | — | 1 | 8.15 |
| CHEMBL4079784 | — | — | 1 | 8.10 |
| CHEMBL4100108 | — | — | 1 | 7.80 |
| CHEMBL4061905 | — | — | 1 | 7.72 |
| CHEMBL4097693 | — | — | 1 | 7.54 |
| CHEMBL4070527 | — | — | 1 | 7.47 |
| CHEMBL4073867 | — | — | 1 | 7.24 |
| CHEMBL4094436 | — | — | 1 | 7.22 |
| CHEMBL4097817 | — | — | 1 | 6.91 |
| CHEMBL4096197 | — | — | 1 | 6.50 |
| CHEMBL4068922 | — | — | 1 | 6.24 |
| CHEMBL4105511 | — | — | 1 | 6.16 |
| CHEMBL4092353 | — | — | 1 | - |
| CHEMBL4080608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL45 | MELATONIN | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL4102177 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4084612 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4062947 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL4095210 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4071572 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4079699 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4089965 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4082097 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4079784 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4100108 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4061905 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4097693 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4070527 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4073867 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4094436 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL4097817 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL4096197 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL4068922 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL4105511 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL4092353 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4080608 | — | Ki | > | 10000.0 | nM | - |