Assay Detail
Functional
CHEMBL3999945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and activity of nucleoside-based antiprotozoan compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL4062813 | — | — | 1 | 6.89 |
| CHEMBL4088825 | — | — | 1 | 5.37 |
| CHEMBL2113602 | — | — | 1 | 5.30 |
| CHEMBL4071448 | — | — | 1 | 5.02 |
| CHEMBL4074699 | — | — | 1 | 4.92 |
| CHEMBL4097315 | — | — | 1 | 4.85 |
| CHEMBL4060076 | — | — | 1 | 4.82 |
| CHEMBL4065059 | — | — | 1 | 4.80 |
| CHEMBL4090399 | — | — | 1 | 4.77 |
| CHEMBL4080501 | — | — | 1 | 4.68 |
| CHEMBL4075657 | — | — | 1 | 4.66 |
| CHEMBL4070000 | — | — | 1 | 4.64 |
| CHEMBL4091995 | — | — | 1 | 4.58 |
| CHEMBL3800167 | — | — | 1 | 4.57 |
| CHEMBL4096088 | — | — | 1 | 4.52 |
| CHEMBL4076916 | — | — | 1 | 4.51 |
| CHEMBL4093177 | — | — | 1 | 4.47 |
| CHEMBL3799739 | — | — | 1 | 4.31 |
| CHEMBL4095187 | — | — | 1 | 4.29 |
| CHEMBL4084731 | — | — | 1 | 4.25 |
| CHEMBL4089844 | — | — | 1 | 4.25 |
| CHEMBL4090762 | — | — | 1 | 4.21 |
| CHEMBL4068736 | — | — | 1 | 4.21 |
| CHEMBL4076818 | — | — | 1 | 4.19 |
| CHEMBL3799380 | — | — | 1 | 4.19 |
| CHEMBL4069803 | — | — | 1 | 4.18 |
| CHEMBL4076721 | — | — | 1 | 4.12 |
| CHEMBL4073644 | — | — | 1 | 4.10 |
| CHEMBL3800333 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4062813 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4088825 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2113602 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4071448 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4074699 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4097315 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4060076 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4065059 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4090399 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4080501 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4075657 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4070000 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4091995 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3800167 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4096088 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4076916 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4093177 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3799739 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4095187 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4084731 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL4089844 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL4090762 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL4068736 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL3799380 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4076818 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL4069803 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4076721 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL4073644 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3800333 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3797375 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4100225 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL4099742 | — | IC50 | = | 203000.0 | nM | - |
| CHEMBL4061466 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL4094270 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3797470 | — | IC50 | = | 206000.0 | nM | - |
| CHEMBL3799800 | — | IC50 | = | 224000.0 | nM | - |
| CHEMBL3799313 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL4102936 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL3799415 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL4105508 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL3798486 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL4085977 | — | IC50 | = | 113000.0 | nM | - |
| CHEMBL3799944 | — | IC50 | = | 194000.0 | nM | - |
| CHEMBL4081985 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL4085214 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL4093664 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL4088363 | — | IC50 | > | 340000.0 | nM | - |
| CHEMBL4067099 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL4066090 | — | IC50 | = | 127000.0 | nM | - |