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Assay Detail

CHEMBL3999946

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis and activity of nucleoside-based antiprotozoan compounds.
Tran HA, Zheng Z, Wen X, Manivannan S, Pastor A, Kaiser M, Brun R, Snyder FF, Back TG.
Bioorg Med Chem (2017) 25 : 2091 -2104
PubMed 28284860 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 5.05 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 7.85
CHEMBL4075657 1 5.51
CHEMBL4090399 1 5.30
CHEMBL4060076 1 5.20
CHEMBL4093177 1 4.89
CHEMBL4091995 1 4.82
CHEMBL4070000 1 4.75
CHEMBL4071448 1 4.62
CHEMBL166 MELARSOPROL 3.0 1 4.54
CHEMBL4074699 1 4.07
CHEMBL76 CHLOROQUINE 4.0 1 4.04
CHEMBL4061466 1 -
CHEMBL4076721 1 -
CHEMBL4097315 1 -
CHEMBL4085214 1 -
CHEMBL4076818 1 -
CHEMBL4105508 1 -
CHEMBL4091532 1 -
CHEMBL4100225 1 -
CHEMBL4090762 1 -
CHEMBL4062813 1 -
CHEMBL4081985 1 -
CHEMBL4066090 1 -
CHEMBL4093664 1 -
CHEMBL4085977 1 -
CHEMBL4067099 1 -
CHEMBL4073644 1 -
CHEMBL4094270 1 -
CHEMBL4084731 1 -
CHEMBL4088363 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 14.0 nM 7.85
CHEMBL4075657 IC50 = 3100.0 nM 5.51
CHEMBL4090399 IC50 = 5000.0 nM 5.30
CHEMBL4060076 IC50 = 6300.0 nM 5.20
CHEMBL4093177 IC50 = 13000.0 nM 4.89
CHEMBL4091995 IC50 = 15000.0 nM 4.82
CHEMBL4070000 IC50 = 18000.0 nM 4.75
CHEMBL4071448 IC50 = 24000.0 nM 4.62
CHEMBL166 MELARSOPROL IC50 = 29000.0 nM 4.54
CHEMBL4074699 IC50 = 86000.0 nM 4.07
CHEMBL76 CHLOROQUINE IC50 = 91000.0 nM 4.04
CHEMBL4100225 IC50 = 144000.0 nM -
CHEMBL4091532 IC50 = 129000.0 nM -
CHEMBL4105508 IC50 = 138000.0 nM -
CHEMBL4076818 IC50 = 141000.0 nM -
CHEMBL4085214 IC50 = 156000.0 nM -
CHEMBL4097315 IC50 = 114000.0 nM -
CHEMBL4076721 IC50 = 259000.0 nM -
CHEMBL4061466 IC50 = 168000.0 nM -
CHEMBL4076916 IC50 = 216000.0 nM -
CHEMBL125 MILTEFOSINE IC50 = 137000.0 nM -
CHEMBL110 BENZNIDAZOLE IC50 > 385000.0 nM -
CHEMBL4090762 IC50 = 185000.0 nM -
CHEMBL4062813 IC50 = 163000.0 nM -
CHEMBL4081985 IC50 = 165000.0 nM -
CHEMBL4066090 IC50 = 211000.0 nM -
CHEMBL4093664 IC50 = 175000.0 nM -
CHEMBL4085977 IC50 = 190000.0 nM -
CHEMBL4067099 IC50 = 158000.0 nM -
CHEMBL4073644 IC50 = 189000.0 nM -
CHEMBL4094270 IC50 = 182000.0 nM -
CHEMBL4084731 IC50 = 155000.0 nM -
CHEMBL4088363 IC50 = 187000.0 nM -