Assay Detail
Binding
CHEMBL3999965
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Displacement of [3H]DPN from zebrafish mu opioid receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Danio rerio |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.47 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.73 |
| CHEMBL4101712 | — | — | 1 | 6.69 |
| CHEMBL4083712 | — | — | 1 | 6.65 |
| CHEMBL4064725 | — | — | 1 | 6.62 |
| CHEMBL4095111 | — | — | 1 | 6.57 |
| CHEMBL4065055 | — | — | 1 | 6.50 |
| CHEMBL4102609 | — | — | 1 | 6.42 |
| CHEMBL13786 | — | — | 1 | 6.17 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL4101712 | — | Ki | = | 202.5 | nM | 6.69 |
| CHEMBL4083712 | — | Ki | = | 223.1 | nM | 6.65 |
| CHEMBL4064725 | — | Ki | = | 239.4 | nM | 6.62 |
| CHEMBL4095111 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL4065055 | — | Ki | = | 312.6 | nM | 6.50 |
| CHEMBL4102609 | — | Ki | = | 383.3 | nM | 6.42 |
| CHEMBL13786 | — | Ki | = | 684.0 | nM | 6.17 |
| CHEMBL8234 | ENKEPHALIN | Ki | = | 1317.0 | nM | 5.88 |