Assay Detail
ADMET
CHEMBL4004666
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Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 5 to 15 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.88 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1109 | SULFAPHENAZOLE | 4.0 | 1 | 6.69 |
| CHEMBL4101807 | VOXELOTOR | 4.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1109 | SULFAPHENAZOLE | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL4101807 | VOXELOTOR | IC50 | = | 8500.0 | nM | 5.07 |