Assay Detail
Functional
CHEMBL4006963
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Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.15 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.03 |
| CHEMBL4105330 | — | — | 1 | 5.98 |
| CHEMBL4062046 | — | — | 1 | 5.73 |
| CHEMBL4088968 | — | — | 1 | 5.65 |
| CHEMBL4081077 | — | — | 1 | 5.60 |
| CHEMBL4090575 | — | — | 1 | 5.49 |
| CHEMBL4098306 | — | — | 1 | 5.24 |
| CHEMBL4071260 | — | — | 1 | 5.15 |
| CHEMBL4061824 | — | — | 1 | 4.88 |
| CHEMBL4089886 | — | — | 1 | 4.45 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.36 |
| CHEMBL1946659 | — | — | 1 | 4.22 |
| CHEMBL1946851 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4105330 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4062046 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4088968 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4081077 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4090575 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4098306 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL4071260 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL4061824 | — | IC50 | = | 13280.0 | nM | 4.88 |
| CHEMBL4089886 | — | IC50 | = | 35690.0 | nM | 4.45 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 43220.0 | nM | 4.36 |
| CHEMBL1946659 | — | IC50 | = | 59700.0 | nM | 4.22 |
| CHEMBL1946851 | — | IC50 | = | 68300.0 | nM | 4.17 |