Assay Detail
Functional
CHEMBL4008249
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Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human respiratory syncytial virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.03 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 2 | 7.82 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.28 |
| CHEMBL4086934 | — | — | 1 | 5.96 |
| CHEMBL2016758 | — | — | 1 | 5.26 |
| CHEMBL4090316 | — | — | 1 | 5.14 |
| CHEMBL4069270 | — | — | 1 | 4.20 |
| CHEMBL2016760 | — | — | 1 | - |
| CHEMBL4065501 | — | — | 1 | - |
| CHEMBL4066445 | — | — | 1 | - |
| CHEMBL3120779 | — | — | 1 | - |
| CHEMBL3120789 | — | — | 1 | - |
| CHEMBL3120793 | GS-6620 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4086934 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2016758 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4090316 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4069270 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL2016760 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL4065501 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4066445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3120779 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3120789 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3120793 | GS-6620 | EC50 | > | 20000.0 | nM | - |