Assay Detail
Binding
CHEMBL4008737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FAAH1 expressed in HEK293 cell membrane-enriched lysate using AMC arachidonyl amide as substrate preincubated for 50 mins followed by substrate addition measured after 4 hrs by fluorescence analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.46 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091498 | — | — | 1 | 9.30 |
| CHEMBL4070196 | — | — | 1 | 9.22 |
| CHEMBL4092052 | — | — | 1 | 9.22 |
| CHEMBL4086944 | — | — | 1 | 9.22 |
| CHEMBL4079093 | — | — | 1 | 9.05 |
| CHEMBL4069565 | — | — | 1 | 9.00 |
| CHEMBL4073966 | — | — | 1 | 8.96 |
| CHEMBL4065510 | — | — | 1 | 8.92 |
| CHEMBL4100735 | — | — | 1 | 8.89 |
| CHEMBL4071240 | — | — | 1 | 8.80 |
| CHEMBL4081780 | — | — | 1 | 8.74 |
| CHEMBL4099798 | — | — | 1 | 8.64 |
| CHEMBL4095588 | — | — | 1 | 8.59 |
| CHEMBL4078351 | — | — | 1 | 8.57 |
| CHEMBL4060896 | — | — | 1 | 8.57 |
| CHEMBL4072282 | — | — | 1 | 8.55 |
| CHEMBL4094794 | — | — | 1 | 8.52 |
| CHEMBL4103339 | — | — | 1 | 8.48 |
| CHEMBL4090581 | — | — | 1 | 8.46 |
| CHEMBL4063681 | — | — | 1 | 8.39 |
| CHEMBL4098174 | — | — | 1 | 8.37 |
| CHEMBL4092900 | — | — | 1 | 8.32 |
| CHEMBL4062484 | — | — | 1 | 8.22 |
| CHEMBL4087889 | — | — | 1 | 8.12 |
| CHEMBL4072140 | — | — | 1 | 8.10 |
| CHEMBL4099236 | — | — | 1 | 7.97 |
| CHEMBL4059573 | — | — | 1 | 7.68 |
| CHEMBL4071121 | — | — | 1 | 7.43 |
| CHEMBL4068218 | — | — | 1 | 7.41 |
| CHEMBL4090459 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091498 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4070196 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4092052 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4086944 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4079093 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4069565 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4073966 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4065510 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4100735 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4071240 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4081780 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4099798 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4095588 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4078351 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4060896 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4072282 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4094794 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4103339 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4090581 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4063681 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4098174 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4092900 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4062484 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4087889 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4072140 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4099236 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL4059573 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4071121 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4068218 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4090459 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4102620 | — | IC50 | = | 63.0 | nM | 7.20 |