Compound Detail
CHEMBL4098174
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Basic Information
| ChEMBL ID | CHEMBL4098174 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KSBOWCQXLJULOX-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
528.5
MW (Da)
6.36
ALogP
5
HBA
1
HBD
54.0
PSA (Ų)
0.33
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.78
IC50 1 meas. best 8.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | EC50 | 8.78 | 7.3667 | 1.7 | 3 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 8.37 | 8.37 | 4.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | EC50 | = | 1.66 | nM | 8.78 | Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 c... | 28182408 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 4.3 | nM | 8.37 | Inhibition of human FAAH1 expressed in HEK293 cell membrane-enriched lysate usin... | 28182408 |
| D(3) dopamine receptor | EC50 | = | 220.0 | nM | 6.66 | Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells ass... | 28182408 |
| D(3) dopamine receptor | EC50 | = | 218.78 | nM | 6.66 | Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells ass... | 28182408 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28182408 | 10.1021/acs.jmedchem.6b01578 | D(3) dopamine receptor | 4 |
| 28182408 | 10.1021/acs.jmedchem.6b01578 | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine