Assay Detail
Binding
CHEMBL4009142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu-type opioid receptor in guinea pig brain membranes after 120 mins by solid scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.78 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.64 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.28 |
| CHEMBL4094571 | — | — | 1 | 7.68 |
| CHEMBL3634516 | — | — | 1 | 7.37 |
| CHEMBL4084350 | — | — | 1 | 7.04 |
| CHEMBL4095192 | — | — | 1 | 6.74 |
| CHEMBL4069231 | — | — | 1 | 6.66 |
| CHEMBL4088788 | — | — | 1 | 6.51 |
| CHEMBL4074031 | — | — | 1 | 6.47 |
| CHEMBL4091184 | — | — | 1 | 6.44 |
| CHEMBL4092100 | — | — | 1 | 6.29 |
| CHEMBL4083401 | — | — | 1 | 6.26 |
| CHEMBL4064380 | — | — | 1 | 6.21 |
| CHEMBL4099849 | — | — | 1 | 6.08 |
| CHEMBL4072972 | — | — | 1 | 5.91 |
| CHEMBL4061582 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80 | NALOXONE | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL70 | MORPHINE | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL4094571 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3634516 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL4084350 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL4095192 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL4069231 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL4088788 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL4074031 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL4091184 | — | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL4092100 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL4083401 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL4064380 | — | Ki | = | 612.0 | nM | 6.21 |
| CHEMBL4099849 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL4072972 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL4061582 | — | Ki | = | 1300.0 | nM | 5.89 |