Assay Detail
Binding
CHEMBL4009955
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Displacement of [3H]DOB from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 mins by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.98 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6616 | — | — | 1 | 9.15 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 9.10 |
| CHEMBL8389 | — | — | 1 | 7.09 |
| CHEMBL8642 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6616 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL8389 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL8642 | — | Ki | = | 268.0 | nM | 6.57 |