Assay Detail
Binding
CHEMBL4009965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat frontal cortex membranes measured after 15 mins by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.85 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927025 | — | — | 1 | 6.71 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 6.41 |
| CHEMBL382757 | — | — | 1 | 5.48 |
| CHEMBL195390 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927025 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL6731 | TENAMFETAMINE | Ki | = | 387.0 | nM | 6.41 |
| CHEMBL382757 | — | Ki | = | 3310.0 | nM | 5.48 |
| CHEMBL195390 | — | Ki | = | 15800.0 | nM | 4.80 |