Assay Detail
Binding
CHEMBL4010460
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Inhibition of SYK (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 25 mins
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new Syk inhibitors through structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.07 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065618 | — | — | 1 | 8.70 |
| CHEMBL2017552 | — | — | 1 | 8.40 |
| CHEMBL512172 | — | — | 1 | 8.22 |
| CHEMBL2017551 | — | — | 1 | 8.10 |
| CHEMBL4103500 | — | — | 1 | 7.70 |
| CHEMBL2347996 | — | — | 1 | 7.58 |
| CHEMBL4077712 | — | — | 1 | 7.39 |
| CHEMBL4104392 | — | — | 1 | 7.33 |
| CHEMBL3125861 | — | — | 1 | 7.00 |
| CHEMBL1458891 | — | — | 1 | 6.92 |
| CHEMBL4104855 | — | — | 1 | 5.72 |
| CHEMBL4079394 | — | — | 1 | 5.50 |
| CHEMBL4103655 | — | — | 1 | 5.48 |
| CHEMBL4067688 | — | — | 1 | 5.47 |
| CHEMBL4077136 | — | — | 1 | 5.40 |
| CHEMBL4089803 | — | — | 1 | 5.15 |
| CHEMBL4090023 | — | — | 1 | 5.00 |
| CHEMBL4062804 | — | — | 1 | 4.77 |
| CHEMBL4100895 | — | — | 1 | 4.70 |
| CHEMBL4075601 | — | — | 1 | 4.62 |
| CHEMBL4082917 | — | — | 1 | 4.57 |
| CHEMBL4104278 | — | — | 1 | 4.55 |
| CHEMBL4070445 | — | — | 1 | 4.55 |
| CHEMBL4099920 | — | — | 1 | 4.52 |
| CHEMBL3192431 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065618 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017552 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL512172 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017551 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4103500 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2347996 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4077712 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4104392 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3125861 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1458891 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4104855 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4079394 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4103655 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4067688 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4077136 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4089803 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4090023 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4062804 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4100895 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4075601 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4082917 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4104278 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL4070445 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4099920 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3192431 | — | IC50 | = | 30900.0 | nM | 4.51 |