Compound Detail
CHEMBL4079394
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4079394 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QEZSOPXFZRHFRF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
2.72
ALogP
3
HBA
2
HBD
78.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor TYRO3 CHEMBL5314 | IC50 | 8.49 | 8.49 | 3.2 | 1 |
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor TYRO3 | IC50 | = | 3.2 | nM | 8.49 | Inhibition of SKY (unknown origin) | 38784451 |
| Tyrosine-protein kinase SYK | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of SYK (unknown origin) using FAM-labeled peptide as substrate preinc... | 28268139 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28268139 | 10.1016/j.bmcl.2017.02.060 | Tyrosine-protein kinase SYK | 2 |
| 28268139 | 10.1016/j.bmcl.2017.02.060 | Unchecked | 1 |
| 38784451 | 10.1039/d4md00003j | Tyrosine-protein kinase receptor TYRO3 | 1 |
Data from ChEMBL 36 via Core Engine