Assay Detail
ADMET
CHEMBL4012483
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Inhibition of human CYP11B1 expressed in HEK293A cells
24
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.83 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088766 | — | — | 1 | 9.22 |
| CHEMBL4082403 | — | — | 3 | 8.96 |
| CHEMBL4070323 | — | — | 1 | 8.22 |
| CHEMBL4099824 | — | — | 1 | 8.00 |
| CHEMBL4070230 | — | — | 1 | 7.96 |
| CHEMBL4072943 | — | — | 1 | 7.89 |
| CHEMBL4093575 | — | — | 1 | 7.89 |
| CHEMBL4091167 | — | — | 1 | 7.80 |
| CHEMBL4092081 | — | — | 1 | 7.72 |
| CHEMBL4079006 | — | — | 1 | 7.38 |
| CHEMBL4065476 | — | — | 1 | 7.03 |
| CHEMBL4061565 | — | — | 1 | 6.96 |
| CHEMBL4072871 | — | — | 1 | 6.91 |
| CHEMBL4104118 | — | — | 1 | 6.74 |
| CHEMBL4077051 | — | — | 1 | - |
| CHEMBL4060559 | — | — | 1 | - |
| CHEMBL4101118 | — | — | 1 | - |
| CHEMBL4075207 | — | — | 1 | - |
| CHEMBL4067686 | — | — | 1 | - |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | - |
| CHEMBL4083387 | — | — | 1 | - |
| CHEMBL4064367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088766 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4082403 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4082403 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4070323 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4099824 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4070230 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4072943 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4093575 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4091167 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4092081 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4079006 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4065476 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4061565 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4072871 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4104118 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4060559 | — | IC50 | - | — | - | |
| CHEMBL4101118 | — | IC50 | - | — | - | |
| CHEMBL4075207 | — | IC50 | - | — | - | |
| CHEMBL4067686 | — | IC50 | - | — | - | |
| CHEMBL4077051 | — | IC50 | - | — | - | |
| CHEMBL287677 | DEXFADROSTAT | IC50 | - | — | - | |
| CHEMBL4083387 | — | IC50 | - | — | - | |
| CHEMBL4064367 | — | IC50 | - | — | - | |
| CHEMBL4082403 | — | IC50 | > | 300.0 | nM | - |