Assay Detail
Binding
CHEMBL4013233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every minute for 10 mins by Ellman's spectrophotometric method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.81 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.49 |
| CHEMBL4074062 | — | — | 1 | 6.58 |
| CHEMBL4084371 | — | — | 1 | 5.79 |
| CHEMBL4095535 | — | — | 1 | 5.75 |
| CHEMBL4066548 | — | — | 1 | 5.72 |
| CHEMBL4094591 | — | — | 1 | 5.52 |
| CHEMBL4068149 | — | — | 1 | 5.51 |
| CHEMBL4102333 | — | — | 1 | 5.48 |
| CHEMBL4099873 | — | — | 1 | 5.44 |
| CHEMBL4072999 | — | — | 1 | 5.42 |
| CHEMBL4064413 | — | — | 1 | 5.32 |
| CHEMBL4081915 | — | — | 1 | 5.23 |
| CHEMBL4094081 | — | — | 1 | 5.22 |
| CHEMBL4076930 | — | — | 1 | - |
| CHEMBL4092048 | — | — | 1 | - |
| CHEMBL4098418 | — | — | 1 | - |
| CHEMBL4092123 | — | — | 1 | - |
| CHEMBL4060011 | — | — | 1 | - |
| CHEMBL4071377 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4074062 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL4084371 | — | IC50 | = | 1615.0 | nM | 5.79 |
| CHEMBL4095535 | — | IC50 | = | 1792.0 | nM | 5.75 |
| CHEMBL4066548 | — | IC50 | = | 1915.0 | nM | 5.72 |
| CHEMBL4094591 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4068149 | — | IC50 | = | 3055.0 | nM | 5.51 |
| CHEMBL4102333 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4099873 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL4072999 | — | IC50 | = | 3815.0 | nM | 5.42 |
| CHEMBL4064413 | — | IC50 | = | 4765.0 | nM | 5.32 |
| CHEMBL4081915 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4094081 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL4076930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4092048 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098418 | — | IC50 | - | — | - | |
| CHEMBL4092123 | — | IC50 | - | — | - | |
| CHEMBL4060011 | — | IC50 | - | — | - | |
| CHEMBL4071377 | — | IC50 | - | — | - |