Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4013312

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP2C9 (unknown origin) using diclofenac as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 2C9 (CHEMBL3397)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Lorthiois E, Anderson K, Vulpetti A, Rogel O, Cumin F, Ostermann N, Steinbacher S, Mac Sweeney A, Delgado O, Liao SM, Randl S, Rüdisser S, Dussauge S, Fettis K, Kieffer L, de Erkenez A, Yang L, Hartwieg C, Argikar UA, La Bonte LR, Newton R, Kansara V, Flohr S, Hommel U, Jaffee B, Maibaum J.
J Med Chem (2017) 60 : 5717 -5735
PubMed 28621538 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.91 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4070311 1 6.82
CHEMBL4094108 1 6.60
CHEMBL4065529 1 6.10
CHEMBL3668698 1 5.60
CHEMBL3908849 1 5.47
CHEMBL3683737 1 5.40
CHEMBL4098439 1 5.37
CHEMBL3668755 1 -
CHEMBL3673825 1 -
CHEMBL3683753 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4070311 IC50 = 150.0 nM 6.82
CHEMBL4094108 IC50 = 250.0 nM 6.60
CHEMBL4065529 IC50 = 800.0 nM 6.10
CHEMBL3668698 IC50 = 2500.0 nM 5.60
CHEMBL3908849 IC50 = 3400.0 nM 5.47
CHEMBL3683737 IC50 = 4000.0 nM 5.40
CHEMBL4098439 IC50 = 4300.0 nM 5.37
CHEMBL3668755 IC50 > 10000.0 nM -
CHEMBL3673825 IC50 > 10000.0 nM -
CHEMBL3683753 IC50 > 20000.0 nM -