Assay Detail
ADMET
CHEMBL4013732
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Agonist activity at human NMUR1 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 8.45 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098010 | — | — | 1 | 9.51 |
| CHEMBL4068681 | — | — | 1 | 9.49 |
| CHEMBL4088263 | — | — | 1 | 9.39 |
| CHEMBL3356083 | — | — | 1 | 9.27 |
| CHEMBL4059530 | — | — | 1 | 9.14 |
| CHEMBL4073946 | — | — | 1 | 9.11 |
| CHEMBL4095998 | — | — | 1 | 9.02 |
| CHEMBL4079986 | — | — | 1 | 9.00 |
| CHEMBL4063830 | — | — | 1 | 8.89 |
| CHEMBL4087867 | — | — | 1 | 8.72 |
| CHEMBL4061507 | — | — | 1 | 8.66 |
| CHEMBL4099780 | — | — | 1 | 8.57 |
| CHEMBL4089636 | — | — | 1 | 8.57 |
| CHEMBL4091611 | — | — | 1 | 8.11 |
| CHEMBL4097355 | — | — | 1 | 8.09 |
| CHEMBL4081760 | — | — | 1 | 8.04 |
| CHEMBL4063341 | — | — | 1 | 8.02 |
| CHEMBL4090300 | — | — | 1 | 7.77 |
| CHEMBL4060571 | — | — | 1 | 7.41 |
| CHEMBL4100718 | — | — | 1 | 7.38 |
| CHEMBL4070175 | — | — | 1 | 7.09 |
| CHEMBL4092033 | — | — | 1 | 6.70 |
| CHEMBL4091208 | — | — | 1 | - |
| CHEMBL4069256 | — | — | 1 | - |
| CHEMBL4071218 | — | — | 1 | - |
| CHEMBL4060027 | — | — | 1 | - |
| CHEMBL4082455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098010 | — | EC50 | = | 0.31 | nM | 9.51 |
| CHEMBL4068681 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4088263 | — | EC50 | = | 0.41 | nM | 9.39 |
| CHEMBL3356083 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL4059530 | — | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4073946 | — | EC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4095998 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL4079986 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4063830 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4087867 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4061507 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4099780 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4089636 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4091611 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4097355 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4081760 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4063341 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4090300 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4060571 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4100718 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4070175 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4092033 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4091208 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4069256 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4071218 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4060027 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4082455 | — | EC50 | > | 1000.0 | nM | - |