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Compound Detail

CHEMBL4070175

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CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O

Basic Information

ChEMBL ID CHEMBL4070175
Phase Preclinical
Structure Type MOL
InChI Key BOGGXPDTHSDHMW-VTWSTLNFSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

1233.5
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C60H84N18O11
MW 1233.45

Activity Summary

EC50 3 meas. best 9.08

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuromedin-U receptor 2
CHEMBL1075144
EC50 9.08 9.08 0.8 1
Neuromedin-U receptor 2
CHEMBL3351217
EC50 8.32 8.32 4.8 1
Neuromedin-U receptor 1
CHEMBL1075178
EC50 7.09 7.09 81.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28657315 10.1021/acs.jmedchem.7b00330 Neuromedin-U receptor 1 2
28657315 10.1021/acs.jmedchem.7b00330 Neuromedin-U receptor 2 2

Data from ChEMBL 36 via Core Engine