Assay Detail
Functional
CHEMBL4015111
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Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ZR-75-30 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 4.85 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.62 |
| CHEMBL4093702 | — | — | 1 | 6.38 |
| CHEMBL4079026 | — | — | 1 | 5.57 |
| CHEMBL4067187 | — | — | 1 | 5.52 |
| CHEMBL4088445 | — | — | 1 | 5.51 |
| CHEMBL4101478 | — | — | 1 | 5.39 |
| CHEMBL4103919 | — | — | 1 | 5.35 |
| CHEMBL4074796 | — | — | 1 | 5.15 |
| CHEMBL4068153 | — | — | 1 | 5.09 |
| CHEMBL4093758 | — | — | 1 | 4.92 |
| CHEMBL4067136 | — | — | 1 | 4.92 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.75 |
| CHEMBL3621817 | — | — | 1 | 4.70 |
| CHEMBL4094596 | — | — | 1 | 4.66 |
| CHEMBL3621822 | — | — | 1 | 4.66 |
| CHEMBL4100746 | — | — | 1 | 4.64 |
| CHEMBL4065363 | — | — | 1 | 4.62 |
| CHEMBL4066333 | — | — | 1 | 4.44 |
| CHEMBL4089337 | — | — | 1 | 4.35 |
| CHEMBL4086886 | — | — | 1 | 4.33 |
| CHEMBL3621821 | — | — | 1 | 4.31 |
| CHEMBL4092057 | — | — | 1 | 4.08 |
| CHEMBL1276861 | — | — | 1 | 4.05 |
| CHEMBL4063413 | — | — | 1 | 4.04 |
| CHEMBL4099805 | — | — | 1 | 4.03 |
| CHEMBL4086002 | — | — | 1 | 4.01 |
| CHEMBL4073002 | — | — | 1 | - |
| CHEMBL4060294 | — | — | 1 | - |
| CHEMBL4066182 | — | — | 1 | - |
| CHEMBL4104762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4093702 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4079026 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4067187 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4088445 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4101478 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4103919 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4074796 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4068153 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4093758 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4067136 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3621817 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3621822 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4094596 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4100746 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4065363 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4066333 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4089337 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4086886 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3621821 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4092057 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL1276861 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4063413 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL4099805 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL4086002 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL3621819 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4083231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061374 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4101832 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4098759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4069285 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3622215 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3622214 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621824 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621837 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4073002 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621818 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621838 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3621815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3621767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4080713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4084303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4097038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4085048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4104762 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4066182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4060294 | — | IC50 | > | 100000.0 | nM | - |