Assay Detail
ADMET
CHEMBL4017362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP2C9 using sulfaphenazole as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.41 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081718 | — | — | 1 | 4.60 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081718 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1259059 | SOFOSBUVIR | IC50 | = | 60000.0 | nM | 4.22 |