Assay Detail
ADMET
CHEMBL4017990
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CYP3A4 expressed in insect cells using DBOMF as substrate pretreated for 10 mins followed by substrate addition measured every minute for 15 mins in presence of NADP+ by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.21 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.70 |
| CHEMBL4076034 | — | — | 1 | 5.43 |
| CHEMBL4075061 | — | — | 1 | 5.04 |
| CHEMBL4070182 | — | — | 1 | 4.86 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4076034 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4075061 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4070182 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL95 | TACRINE | IC50 | = | 96900.0 | nM | 4.01 |