Assay Detail
Functional
CHEMBL4019385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Varicella-Zoster virus OKA infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 5.04 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 6.21 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.73 |
| CHEMBL4092749 | — | — | 1 | 5.70 |
| CHEMBL4070453 | — | — | 1 | 5.58 |
| CHEMBL4071975 | — | — | 1 | 5.43 |
| CHEMBL4069049 | — | — | 1 | 5.38 |
| CHEMBL4089384 | — | — | 1 | 5.37 |
| CHEMBL4080028 | — | — | 1 | 5.36 |
| CHEMBL4096537 | — | — | 1 | 5.30 |
| CHEMBL4068202 | — | — | 1 | 5.21 |
| CHEMBL4102245 | — | — | 1 | 5.21 |
| CHEMBL4097094 | — | — | 1 | 5.19 |
| CHEMBL22101 | — | — | 1 | 5.16 |
| CHEMBL4094506 | — | — | 1 | 5.14 |
| CHEMBL4065338 | — | — | 1 | 5.14 |
| CHEMBL4068046 | — | — | 1 | 5.06 |
| CHEMBL4105334 | — | — | 1 | 5.03 |
| CHEMBL4078913 | — | — | 1 | 5.02 |
| CHEMBL4088970 | — | — | 1 | 4.99 |
| CHEMBL4086769 | — | — | 1 | 4.89 |
| CHEMBL4104266 | — | — | 1 | 4.89 |
| CHEMBL4073948 | — | — | 1 | 4.87 |
| CHEMBL4067754 | — | — | 1 | 4.87 |
| CHEMBL4095438 | — | — | 1 | 4.79 |
| CHEMBL4086927 | — | — | 1 | 4.77 |
| CHEMBL4104805 | — | — | 1 | 4.77 |
| CHEMBL4097626 | — | — | 1 | 4.68 |
| CHEMBL4059557 | — | — | 1 | 4.66 |
| CHEMBL4084278 | — | — | 1 | 4.66 |
| CHEMBL4082027 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1540 | PENCICLOVIR | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4092749 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4070453 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4071975 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4069049 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4089384 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4080028 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4096537 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4068202 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4102245 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4097094 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL22101 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4094506 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4065338 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4068046 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4105334 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4078913 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4088970 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4086769 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4104266 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4067754 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4073948 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4095438 | — | EC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4086927 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4104805 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4097626 | — | EC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4059557 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4084278 | — | EC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4082027 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL42992 | — | EC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4072783 | — | EC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4103193 | — | EC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL4081507 | — | EC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL4100038 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4079072 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4069305 | — | EC50 | - | — | - | |
| CHEMBL4088839 | — | EC50 | - | — | - | |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL4081082 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4096665 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4071000 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4078649 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4099669 | — | EC50 | >= | 23500.0 | nM | - |