Assay Detail
Functional
CHEMBL4021091
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Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9859 | — | — | 1 | 8.52 |
| CHEMBL4081485 | — | — | 1 | 7.19 |
| CHEMBL4070903 | — | — | 1 | 6.86 |
| CHEMBL4091771 | — | — | 1 | 6.61 |
| CHEMBL4091289 | — | — | 1 | 6.55 |
| CHEMBL4073627 | — | — | 1 | 6.34 |
| CHEMBL4099511 | — | — | 1 | 6.30 |
| CHEMBL4099765 | — | — | 1 | 6.25 |
| CHEMBL4083996 | — | — | 1 | 6.24 |
| CHEMBL4099025 | — | — | 1 | 6.08 |
| CHEMBL4062280 | — | — | 1 | 5.65 |
| CHEMBL4088886 | — | — | 1 | 5.53 |
| CHEMBL4060662 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9859 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4081485 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4070903 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4091771 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL4091289 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL4073627 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4099511 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL4099765 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL4083996 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL4099025 | — | IC50 | = | 839.0 | nM | 6.08 |
| CHEMBL4062280 | — | IC50 | = | 2224.0 | nM | 5.65 |
| CHEMBL4088886 | — | IC50 | = | 2932.0 | nM | 5.53 |
| CHEMBL4060662 | — | IC50 | = | 5294.0 | nM | 5.28 |