Assay Detail
Binding
CHEMBL4022076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+)-[3H]-ditolylguanidine from recombinant rat sigma 2 receptor expressed in rat PC12 cell membranes after 90 mins in presence of sigma 1 receptor blocker (+)-SKF-10047 by scintillation counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Reevaluation of fenpropimorph as a σ receptor ligand: Structure-affinity relationship studies at human σ1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.78 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101014 | — | — | 1 | 7.86 |
| CHEMBL4083034 | — | — | 1 | 7.50 |
| CHEMBL4071509 | — | — | 1 | 7.18 |
| CHEMBL4098546 | — | — | 1 | 7.11 |
| CHEMBL372700 | FENPROPIMORPH | — | 1 | 6.07 |
| CHEMBL4090823 | — | — | 1 | 6.03 |
| CHEMBL1562542 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101014 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL4083034 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL4071509 | — | Ki | = | 66.1 | nM | 7.18 |
| CHEMBL4098546 | — | Ki | = | 77.9 | nM | 7.11 |
| CHEMBL372700 | FENPROPIMORPH | Ki | = | 854.0 | nM | 6.07 |
| CHEMBL4090823 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL1562542 | — | Ki | = | 2019.0 | nM | 5.70 |