Assay Detail
Binding
CHEMBL4023573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine BChE using BTC iodide as substrate preincubated for 4.5 mins followed by substrate addition measured after 2.5 mins by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079520 | — | — | 1 | 6.16 |
| CHEMBL4082936 | — | — | 1 | 5.64 |
| CHEMBL4100917 | — | — | 1 | 5.43 |
| CHEMBL471980 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079520 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4082936 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4100917 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL471980 | — | IC50 | = | 9700.0 | nM | 5.01 |