Assay Detail
ADMET
CHEMBL4025654
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Inhibition of human hepatic CYP3A4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.34 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068802 | — | — | 1 | 6.16 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 5.57 |
| CHEMBL4064141 | — | — | 1 | 5.28 |
| CHEMBL4063960 | — | — | 1 | 5.18 |
| CHEMBL4101612 | — | — | 1 | 5.10 |
| CHEMBL4059780 | — | — | 1 | 5.07 |
| CHEMBL4091726 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068802 | — | IC50 | = | 685.0 | nM | 6.16 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4064141 | — | IC50 | = | 5282.0 | nM | 5.28 |
| CHEMBL4063960 | — | IC50 | = | 6526.0 | nM | 5.18 |
| CHEMBL4101612 | — | IC50 | = | 7897.0 | nM | 5.10 |
| CHEMBL4059780 | — | IC50 | = | 8561.0 | nM | 5.07 |
| CHEMBL4091726 | — | IC50 | = | 9032.0 | nM | 5.04 |