Assay Detail
Functional
CHEMBL4025745
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Cytotoxicity against human LNCAP cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel aryl piperazines for alleviation of 'andropause' associated prostatic disorders and depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 4.49 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | 5.16 |
| CHEMBL4064849 | — | — | 1 | 4.98 |
| CHEMBL4091788 | — | — | 1 | 4.93 |
| CHEMBL4077464 | — | — | 1 | 4.91 |
| CHEMBL4099982 | — | — | 1 | 4.91 |
| CHEMBL4059948 | — | — | 1 | 4.81 |
| CHEMBL4080495 | — | — | 1 | 4.60 |
| CHEMBL4076135 | — | — | 1 | 4.40 |
| CHEMBL4072518 | — | — | 1 | 4.40 |
| CHEMBL4096236 | — | — | 1 | 4.33 |
| CHEMBL4087799 | — | — | 1 | 4.31 |
| CHEMBL4081976 | — | — | 1 | 4.26 |
| CHEMBL4074576 | — | — | 1 | 4.20 |
| CHEMBL4074143 | — | — | 1 | 4.17 |
| CHEMBL4098512 | — | — | 1 | 4.15 |
| CHEMBL4069699 | — | — | 1 | 4.14 |
| CHEMBL4068964 | — | — | 1 | 4.11 |
| CHEMBL4095418 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL806 | FLUTAMIDE | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4064849 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4091788 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4077464 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4099982 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4059948 | — | EC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4080495 | — | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL4076135 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4072518 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4096236 | — | EC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL4087799 | — | EC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL4081976 | — | EC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL4074576 | — | EC50 | = | 63200.0 | nM | 4.20 |
| CHEMBL4074143 | — | EC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4098512 | — | EC50 | = | 71200.0 | nM | 4.15 |
| CHEMBL4069699 | — | EC50 | = | 72200.0 | nM | 4.14 |
| CHEMBL4068964 | — | EC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL4095418 | — | EC50 | = | 78700.0 | nM | 4.10 |