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Compound Detail

CHEMBL4096236

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COc1ccccc1N1CCN(CCN2CCN(c3ccc([N+](=O)[O-])cc3)CC2)CC1

Basic Information

ChEMBL ID CHEMBL4096236
Phase Preclinical
Structure Type MOL
InChI Key CRNRHSZDXOBMRL-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

425.5
MW (Da)
2.55
ALogP
7
HBA
0
HBD
65.3
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H31N5O3
MW 425.53
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -1.40

Activity Summary

EC50 1 meas. best 4.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
LNCaP
CHEMBL612518
EC50 4.33 4.33 46500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
LNCaP EC50 = 46500.0 nM 4.33 Cytotoxicity against human LNCAP cells after 24 hrs by MTT assay 28363155

Literature References

PubMed DOI Target Context # Activities
28363155 10.1016/j.ejmech.2017.03.036 LNCaP 1

Data from ChEMBL 36 via Core Engine