Assay Detail
Functional
CHEMBL4028772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU145 cells after 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.57 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 10.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL4102788 | — | — | 1 | 7.74 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4102788 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL107 | COLCHICINE | IC50 | = | 25.7 | nM | 7.59 |