Assay Detail
ADMET
CHEMBL4029973
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Inhibition of human CYP11B1-8C7 expressed in Chinese hamster V79 cells using 11-deoxycortisol as substrate preincubated for 1 hr followed by substrate addition measured for 3 hrs by HTRF assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.65 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096914 | — | — | 1 | 8.96 |
| CHEMBL4069720 | — | — | 1 | 8.74 |
| CHEMBL4075377 | — | — | 1 | 7.97 |
| CHEMBL4080420 | — | — | 1 | 7.66 |
| CHEMBL4101709 | — | — | 1 | 7.33 |
| CHEMBL4067000 | — | — | 1 | 7.01 |
| CHEMBL4081339 | — | — | 1 | 6.83 |
| CHEMBL4091491 | — | — | 1 | 6.71 |
| CHEMBL4061038 | — | — | 1 | 6.68 |
| CHEMBL4098297 | — | — | 1 | 6.47 |
| CHEMBL4080256 | — | — | 1 | 6.41 |
| CHEMBL4075484 | — | — | 1 | 6.33 |
| CHEMBL4096817 | — | — | 1 | 6.28 |
| CHEMBL4083708 | — | — | 1 | 6.27 |
| CHEMBL4082750 | — | — | 1 | 6.11 |
| CHEMBL4071689 | — | — | 1 | 6.07 |
| CHEMBL4100299 | — | — | 1 | 6.04 |
| CHEMBL4100151 | — | — | 1 | 6.00 |
| CHEMBL4073305 | — | — | 1 | 5.92 |
| CHEMBL4063670 | — | — | 1 | 5.89 |
| CHEMBL4070125 | — | — | 1 | 5.85 |
| CHEMBL4078791 | — | — | 1 | 5.77 |
| CHEMBL4085626 | — | — | 1 | 5.70 |
| CHEMBL4089111 | — | — | 1 | - |
| CHEMBL4089210 | — | — | 1 | - |
| CHEMBL4067905 | — | — | 1 | - |
| CHEMBL4099361 | — | — | 1 | - |
| CHEMBL4076806 | — | — | 1 | - |
| CHEMBL4063214 | — | — | 1 | - |
| CHEMBL4099223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096914 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4069720 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4075377 | — | IC50 | = | 10.74 | nM | 7.97 |
| CHEMBL4080420 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4101709 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4067000 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4081339 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4091491 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL4061038 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4098297 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL4080256 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL4075484 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4096817 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4083708 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL4082750 | — | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL4071689 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL4100299 | — | IC50 | = | 916.0 | nM | 6.04 |
| CHEMBL4100151 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4073305 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4063670 | — | IC50 | = | 1299.0 | nM | 5.89 |
| CHEMBL4070125 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4078791 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4085626 | — | IC50 | = | 1987.0 | nM | 5.70 |
| CHEMBL4089111 | — | IC50 | > | 8300.0 | nM | - |
| CHEMBL4089210 | — | IC50 | - | — | - | |
| CHEMBL4067905 | — | IC50 | > | 8300.0 | nM | - |
| CHEMBL4099361 | — | IC50 | > | 8300.0 | nM | - |
| CHEMBL4076806 | — | IC50 | > | 8300.0 | nM | - |
| CHEMBL4063214 | — | IC50 | > | 8300.0 | nM | - |
| CHEMBL4099223 | — | IC50 | > | 8300.0 | nM | - |
| CHEMBL4072268 | — | IC50 | > | 8300.0 | nM | - |