Assay Detail
Binding
CHEMBL4031999
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Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.42 | 10.32 |
| Inhibition | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103328 | — | — | 2 | 10.32 |
| CHEMBL4065490 | — | — | 2 | 9.62 |
| CHEMBL326684 | — | — | 2 | 9.60 |
| CHEMBL607405 | — | — | 2 | 9.49 |
| CHEMBL4088589 | — | — | 2 | 9.47 |
| CHEMBL607351 | — | — | 2 | 9.35 |
| CHEMBL4074110 | — | — | 2 | 8.78 |
| CHEMBL963 | OXYMORPHONE | 4.0 | 2 | 8.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103328 | — | Ki | = | 0.048 | nM | 10.32 |
| CHEMBL4065490 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL326684 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL607405 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL4088589 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL607351 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL4074110 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL963 | OXYMORPHONE | Ki | = | 1.79 | nM | 8.75 |
| CHEMBL963 | OXYMORPHONE | Inhibition | - | % | - | |
| CHEMBL4074110 | — | Inhibition | - | % | - | |
| CHEMBL607405 | — | Inhibition | - | % | - | |
| CHEMBL4065490 | — | Inhibition | - | % | - | |
| CHEMBL607351 | — | Inhibition | - | % | - | |
| CHEMBL4103328 | — | Inhibition | - | % | - | |
| CHEMBL326684 | — | Inhibition | - | % | - | |
| CHEMBL4088589 | — | Inhibition | - | % | - |