Assay Detail
Functional
CHEMBL4032004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.78 | 9.89 |
| Activity | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103328 | — | — | 2 | 9.89 |
| CHEMBL607351 | — | — | 2 | 9.49 |
| CHEMBL4065490 | — | — | 2 | 8.86 |
| CHEMBL607405 | — | — | 2 | 8.84 |
| CHEMBL4088589 | — | — | 2 | 8.53 |
| CHEMBL326684 | — | — | 2 | 8.48 |
| CHEMBL963 | OXYMORPHONE | 4.0 | 2 | 8.11 |
| CHEMBL4074110 | — | — | 2 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103328 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL607351 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4065490 | — | EC50 | = | 1.37 | nM | 8.86 |
| CHEMBL607405 | — | EC50 | = | 1.45 | nM | 8.84 |
| CHEMBL4088589 | — | EC50 | = | 2.95 | nM | 8.53 |
| CHEMBL326684 | — | EC50 | = | 3.28 | nM | 8.48 |
| CHEMBL963 | OXYMORPHONE | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4074110 | — | EC50 | = | 8.99 | nM | 8.05 |
| CHEMBL963 | OXYMORPHONE | Activity | - | — | - | |
| CHEMBL4074110 | — | Activity | - | — | - | |
| CHEMBL607405 | — | Activity | - | — | - | |
| CHEMBL4065490 | — | Activity | - | — | - | |
| CHEMBL607351 | — | Activity | - | — | - | |
| CHEMBL4103328 | — | Activity | - | — | - | |
| CHEMBL326684 | — | Activity | - | — | - | |
| CHEMBL4088589 | — | Activity | - | — | - |