Assay Detail
Functional
CHEMBL4032574
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Antiproliferative activity against human T47D cells after 72 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.60 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270686 | MERIOLIN 3 | — | 1 | 6.70 |
| CHEMBL405665 | MERIOLIN 1 | — | 1 | 5.10 |
| CHEMBL4095226 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270686 | MERIOLIN 3 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL405665 | MERIOLIN 1 | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4095226 | — | IC50 | = | 10000.0 | nM | 5.00 |