Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4039164

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human dopamine D3 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(3) dopamine receptor (CHEMBL234)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Lindsley CW, Hopkins CR.
J Med Chem (2017) 60 : 7233 -7243
PubMed 28489950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.78 6.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4096543 1 6.84
CHEMBL81330 1 6.62
CHEMBL444309 1 6.32
CHEMBL346389 1 6.17
CHEMBL4104272 1 5.83
CHEMBL267014 L-745870 1 5.64
CHEMBL4095082 1 5.57
CHEMBL146556 1 5.55
CHEMBL4069306 1 5.49
CHEMBL7927 FAUC 113 1 5.30
CHEMBL310843 1 5.28
CHEMBL3335537 1 4.80
CHEMBL127257 1 -
CHEMBL4068924 1 -
CHEMBL66227 1 -
CHEMBL69759 SONEPIPRAZOLE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4096543 Ki = 145.0 nM 6.84
CHEMBL81330 Ki = 240.0 nM 6.62
CHEMBL444309 Ki = 480.0 nM 6.32
CHEMBL346389 Ki = 679.0 nM 6.17
CHEMBL4104272 Ki = 1480.0 nM 5.83
CHEMBL267014 L-745870 Ki = 2310.0 nM 5.64
CHEMBL4095082 Ki = 2682.0 nM 5.57
CHEMBL146556 Ki = 2840.0 nM 5.55
CHEMBL4069306 Ki = 3210.0 nM 5.49
CHEMBL7927 FAUC 113 Ki = 5000.0 nM 5.30
CHEMBL310843 Ki = 5300.0 nM 5.28
CHEMBL3335537 Ki = 15700.0 nM 4.80
CHEMBL127257 Ki > 6000.0 nM -
CHEMBL4068924 Ki > 3030.0 nM -
CHEMBL66227 Ki > 2000.0 nM -
CHEMBL69759 SONEPIPRAZOLE Ki > 2778.0 nM -