Assay Detail
Binding
CHEMBL4039167
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Inhibition of serotonin 5-HT2 receptor (unknown origin)
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.67 | 8.24 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81330 | — | — | 1 | 8.24 |
| CHEMBL267014 | L-745870 | — | 1 | 6.70 |
| CHEMBL4096543 | — | — | 1 | 6.56 |
| CHEMBL127257 | — | — | 1 | 6.43 |
| CHEMBL66227 | — | — | 1 | 6.30 |
| CHEMBL346389 | — | — | 1 | 5.78 |
| CHEMBL4068924 | — | — | 1 | - |
| CHEMBL103772 | — | — | 1 | - |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81330 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL267014 | L-745870 | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4096543 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL127257 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL66227 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL346389 | — | Ki | = | 1678.0 | nM | 5.78 |
| CHEMBL4068924 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL103772 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | > | 1600.0 | nM | - |