Assay Detail
Binding
CHEMBL4039173
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Inhibition of alpha2A adrenergic receptor (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.59 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 6.77 |
| CHEMBL146556 | — | — | 1 | 6.60 |
| CHEMBL346389 | — | — | 1 | 6.39 |
| CHEMBL127257 | — | — | 1 | - |
| CHEMBL4068924 | — | — | 1 | - |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL146556 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL346389 | — | Ki | = | 411.0 | nM | 6.39 |
| CHEMBL127257 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL4068924 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | > | 1600.0 | nM | - |