Assay Detail
Binding
CHEMBL4039175
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Inhibition of alpha2C adrenergic receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.28 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 6.64 |
| CHEMBL146556 | — | — | 1 | 6.47 |
| CHEMBL127257 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL146556 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL127257 | — | Ki | = | 1912.0 | nM | 5.72 |