Assay Detail
Binding
CHEMBL4039178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sigma1 receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.51 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146556 | — | — | 1 | 8.80 |
| CHEMBL4096543 | — | — | 1 | 7.09 |
| CHEMBL346389 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146556 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4096543 | — | Ki | = | 82.1 | nM | 7.09 |
| CHEMBL346389 | — | Ki | = | 232.0 | nM | 6.63 |