Assay Detail
Functional
CHEMBL4040184
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Antiviral activity against CXCR4-tropic HIV-1 NL4-3 infected in human TZM-bl cells assessed as inhibition of virus-induced cytopathic effect preincubated with cells for 30 mins followed by viral infection measured after 48 hrs in presence of p-24 HIV-1 Ag by luciferase reporter gene assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.52 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070180 | — | — | 1 | 8.00 |
| CHEMBL4089642 | — | — | 1 | 7.14 |
| CHEMBL4073327 | — | — | 1 | 6.85 |
| CHEMBL4099787 | — | — | 1 | 6.80 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.40 |
| CHEMBL93006 | — | — | 1 | 5.34 |
| CHEMBL329554 | — | — | 1 | 5.32 |
| CHEMBL519667 | — | — | 1 | 5.22 |
| CHEMBL482465 | — | — | 1 | 4.53 |
| CHEMBL4082499 | — | — | 1 | 4.38 |
| CHEMBL4062343 | — | — | 1 | 4.27 |
| CHEMBL270618 | — | — | 1 | 4.26 |
| CHEMBL2030736 | — | — | 1 | 4.25 |
| CHEMBL4097362 | — | — | 1 | - |
| CHEMBL4078094 | — | — | 1 | - |
| CHEMBL4081770 | — | — | 1 | - |
| CHEMBL4080837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070180 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4089642 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4073327 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4099787 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL93006 | — | EC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL329554 | — | EC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL519667 | — | EC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL482465 | — | EC50 | = | 29240.0 | nM | 4.53 |
| CHEMBL4082499 | — | EC50 | = | 41860.0 | nM | 4.38 |
| CHEMBL4062343 | — | EC50 | = | 54110.0 | nM | 4.27 |
| CHEMBL270618 | — | EC50 | = | 54800.0 | nM | 4.26 |
| CHEMBL2030736 | — | EC50 | = | 56770.0 | nM | 4.25 |
| CHEMBL4097362 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4078094 | — | EC50 | > | 43440.0 | nM | - |
| CHEMBL4081770 | — | EC50 | > | 54190.0 | nM | - |
| CHEMBL4080837 | — | EC50 | > | 68980.0 | nM | - |