Assay Detail
Functional
CHEMBL4040187
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Antiviral activity against CXCR4-tropic HIV-1 NL4-3 infected in human PHA-stimulated PBMC assessed as inhibition of viral replication by measuring reduction in p24 antigen production preincubated with cells for 30 mins followed by viral infection measured on day 10 post infection in presence of IL-2 by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.05 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | 4.0 | 1 | 9.00 |
| CHEMBL4070180 | — | — | 1 | 8.52 |
| CHEMBL4089642 | — | — | 1 | 7.70 |
| CHEMBL4073327 | — | — | 1 | 7.58 |
| CHEMBL4099787 | — | — | 1 | 7.52 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 7.10 |
| CHEMBL329554 | — | — | 1 | 6.55 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.42 |
| CHEMBL519667 | — | — | 1 | 5.92 |
| CHEMBL93006 | — | — | 1 | 5.85 |
| CHEMBL482465 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4070180 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4089642 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4073327 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4099787 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL329554 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL519667 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL93006 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL482465 | — | IC50 | = | 4040.0 | nM | 5.39 |